Therapeutic effects of albendazole on kidney functions and urinary excretion of florfenicol was determined in goats. After restraining the animals, 600 mg dose of florfenicol was administered intramuscularly. Blood and urine samples were collected, at different time intervals, post-medication. After a washout period of 7 days, florfenicol was administrated along with a 150 mg dose of albendazole. Blood and urine samples were collected at similar time intervals as done previously. Serum was separated by centrifugation and both serum and urine samples were stored at -20ºC until analysis. Drug concentration in samples was determined by using HPLC method. Endogenous creatinine is used as an index of GFR (glomerular filtration rate) and was estimated both in serum and urine samples. Concentrations of drug and creatinine were used to calculate the renal clearance and urinary excretion. Calculated Mean ± SE of renal clearance of florfenicol was 3.32 ± 0.60 and 3.90 ± 0.52 ml/min/kg when given alone and along with albendazole respectively. Influence of serum concentration, diuresis and urinary pH on renal clearance was determined by least square regression/ correlation analysis. Mean ± SEM of urinary excretion expressed as cumulative percent of dose excreted in the urine of goats was 35.81 ± 2.47 and 37.48 ± 2.60, when florfenicol was given alone and along with albendazole respectively. Conclusion and Results were analyzed by student “t” test and it is concluded that there is significant drug- drug interaction between florfenicol and albendazole.
Zunaira Alina, Sumaira Noreen, Ramsha Abbas, Shahneel Kousar, Laiba Riaz, Hira Naeem, Abida Niazi, Hira Ijaz, Syeda Fiza Raza Bukhari, Sadia Ashraf, Muhammad Shoaib and Faiza Naseer
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