Febrile seizures are the most common seizures in the childhood. The exact aetiopathogenesis of febrile seizures is unknown. Objectives: The present study was conducted to evaluate the serum Zinc (Zn), Copper (Cu), Magnesium (Mg) and plasma Malondialdehyde (MDA) levels in patients with febrile seizures (FS). Methods: The study subjects included 20 cases of children with FS, 20 children with only fever and 20 healthy children as controls. Children of 6months â€“ 5 yrs were included in the study group. The Zn, Cu, MDA levels were analyzed by spectrophotometer and Mg by auto analyzer. Results: The mean serum Zn and Mg values were significantly decreased in FS in comparison to children with only fever and control group (P < 0.05). The mean serum Cu and plasma MDA levels were increased in FS children when compared with other two groups (P < 0.05). Conclusion: The findings of the present study suggest that high serum Cu and plasma MDA; reduced serum Zn and Mg may be responsible for enhanced neuronal excitability in children with febrile seizures.