It was 2012 when the first case of corona virus noticed by the Saudi Authorities which spread through the Asian countries, also flown to European countries. In 1960 revealed the presence of the corona virus when it was declared as the reason of common cold in human beings. On January 30, 2020, the WHO declared the COVID-19 outbreak a global health emergency. On March 11, 2020, the WHO declared COVID-19 a global pandemic. There are three brands of vaccines available that are Pfizer, Moderna and Johnson & Johnson (Janssen). A mild difference may present as post vaccination effects. The Pfizer–BioNTech COVID-19 vaccine is based as mRNA and marketed as Comirnaty. Pfizer reported a 91 percent efficacy rate after six months, while Moderna reported a 94 percent efficacy rate. Moderna, we are pioneering a class of medicines based on messenger RNA (mRNA). The Janssen COVID-19 Vaccine may not protect everyone. Mostly 2 doses of the vaccine are required to protect and these are intramuscular injections. Its quantity would be changed in different age groups. Some common side effects include fatigue, headache, and pain in joints, fever, chills, and muscle pain. However everyone should vaccinated for protection of corona virus disease.