Introduction: Cardiovascular Disease (CVD) is the leading cause of death in Kazakhstan. In the structure of CVD, hypertension takes the first place and leads to remodeling of the myocardium and carotid arteries, which significantly increases cardiovascular risk. A number of studies have been carried out that established the genetic characteristics associated with the risk of hypertension and target organ damage in hypertension, but not in Kazakh population.
The aim of this project is to study the molecular genetic predictors of remodeling of the cardiovascular system in HTN in Kazakh population.
Materials and methods: The sample size is 1000 people. There were 4 groups of 250 hypertensive individuals, age - up to 61 years.
Group without remodeling
with carotid artery remodeling (CR), intima-media complex (IMC) > 0.9 mm
with myocardial remodeling (MR) LVMI ≥115 in men, ≥95 in women, relative wall thickness ≥0.43
With remodeling of the myocardium and carotid artery.
Clinical, laboratory, instrumental data were collected. Biological samples were taken for genotyping for 120 SNPs known by association with a thickening of IMC or with left ventricular hypertrophy based on GWAS Catalog - EMBL-EBI and Varsome Clinical and PubMed publications. Genotyping was performed using QuantStudio 12K Flex Real-Time PCR System using array technology.
Preliminary Results: According to a preliminary analysis of 120 SNPs, three polymorphic variants (rs75330306, rs1879734, rs12465515 (p <0.05)) are associated with MR, because of a significant association in groups with MR and in the group RM+CR. rs1879734 and rs12465515 were previously associated with mitral valve prolapse in the European population, and rs75330306 was previously associated with Idiopathic dilated cardiomyopathy in the African American ancestry.