SARS-CoV-2 Post Vaccination Disease Infection Tracking: Breakthrough Casesin Pakistan

Background: The available COVID-19 vaccine claims to present good protection against infection. However, none of them offers 100% safety to counter the disease. Since the start of the vaccination program, there are reports from different parts of the world mentioning the individuals have developed COVID-19 infection after administration of two doses of vaccine.

Case: The brief report presents incidents of SARS-CoV-2 re- infection in two vaccinated individuals despite evidence that two doses of vaccine (Sino pharm) led to antibody production against spike proteins. Both the individuals gave history of travel and close contact with an infected patient. One of the individual presented with respiratory distress symptoms but none of them develop signs of Disseminated Intravascular Coagulation (DIC). No significant findings in chest X-ray and High Resolution Computed Tomography (HRCT) were unremarkable even with the drop of oxygen saturation to 91%. There is a rarity of reported occurrence of SARS-CoV-2 infection after two jabs, particularly from Pakistan.

Conclusion: The study reveals that post vaccination COVID-19 infection reduces the morbidity and mortality rate by controlling the derangements initiating the disseminating intravascular coagulation. The vaccine breakthrough incident puts light on the significance of constant public health monitoring and contingency protective measurements. Our findings may help to pave down further guidelines regarding changing scenario of the pandemic in a country with limited resources and huge population burden.


Aaysha Tariq1 *, Ahmad Farooq1 , Talat Mehmood1 , Rashid Rehman1 , Bakhtawar Abbas1 and Rehan Ahmed Siddiqui2

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